'Bone regeneration using tissue engineering and CAD-CAM techonolgy: Their impact on facial bone reconstruction'

Ablative surgery or major facial trauma in the maxillofacial area leads to bone defects that predispose functional as well as aesthetic complications. The bone defects of the facial skeleton need immediate reconstruction to provide satisfactory function of the jaws as well as an acceptable aesthetic outcome.

Reconstruction of the maxillofacial area with composite microvascular flaps is challenging and needs a team with experienced surgeons. The surgery is time consuming not only because of the microvascular procedures themselves, but due to demand for optimize intraoperatively the configuration and symmetry of the facial skeleton.

The development of three-dimensional (3D) computerized modelling in medicine has been rapid during the last years. However, the use of above mentioned CAD-CAM (computer aided design and manufacturing) is still limited. The technology gives tools for surgeons to plan and to train virtually for the surgery, to design, and manufacture the implants needed for the surgery.

Bone tissue engineering requires several constructive factors. These include among others biocompatible scaffolds and matrices, cells, osteo- and angioinductive growth factors. Modern 3D CAD-CAM technology enables patient-specific scaffold and matrix manufacturing. The scaffold, matrix or implant temporarily replaces the missing part of jaw and allows cells to generate bone accordingly leading to anatomic and symmetrical restoration. Increasing number of studies, both experimental and clinical, are available that show bone regeneration in facial bone defects using CAD-CAM technology, patient-specific matrices and cells.

Current call: 2016